Objective: Immunodeficiency of end-stage renal disease (ESRD) is caused by several factors including uremic toxins and biocompatibility reactions due to the repeated hemodialysis (HD) procedure.
20:00 / 04.08.2014 подробнее Inflammaging: should this term be suitable for age related macular degeneration too?Introduction: Inflammaging is a phenomenon triggered by the conjunction of chronic repetitive and subclinical inflammation from external aggressors and internal inflammatory mechanisms due to the progressive degradation of systems such as the mitochondrial function.
20:00 / 04.08.2014 подробнее Biphasic activation of nuclear factor kappa B and expression of p65 and c-Rel after traumatic brain injury in ratsNuclear factor kappa B (NF-κB) functions as a key regulator in the central nervous system and regulates the inflammatory pathway. There are two peaks of cerebral NF-κB activation after neonatal hypoxia–ischemia and subarachnoid hemorrhage.
20:00 / 04.08.2014 подробнее The expression of IL-2 and IL-4 in CD4+ T cells from mouse lymph nodes and spleen during HSV-1-induced facial palsyObjective: Herpes simplex virus 1 (HSV-1) is regarded as an important underlying cause of Bell’s palsy, but the immunologic mechanism remains unknown.
20:00 / 04.08.2014 подробнее Anti-inflammatory and anti-arthritic effects of 3-hydroxy, 2-methoxy sodium butanoate from the leaves of Clerodendrum phlomidis L.f.Introduction: The leaves of Clerodendrum phlomidis L.f. have been used in the Indian traditional system of medicine to treat several inflammatory diseases and arthritis.
20:00 / 04.08.2014 подробнее Модель экспрессии Нискарина, вызванной липополисахарид (LPS)-индуцированным нейровоспалением в коре мозга крысЦель: Выяснить, участвует ли Нискарин через фосфатидилинозитол - 3 - киназу (PI3K) и РКВ-зивисимый путь в апоптозе нейронов, вызванном нейровоспалением.
20:00 / 16.02.2014 подробнее Ингибирование продукции провосполительных цитокинов посредством ингибирования NF-κB сигнального пути в человеческих тучных клетках (линия HMC-1) с помощью СилибининаЦель: Силибинин - главная активная молекула силимарина, извлеченная из Cirsium japonicum.
20:00 / 16.02.2014 подробнее Подавление продукции цитокина Th1 пептидом, полученным из C4bЦель: Система комплимента играет существенную роль в регулировании T-клеточных реакций. Однако, точный механизм, лежащий в основе C4-индуцируемой иммунотолерантности, остается неясным.
20:00 / 16.02.2014 подробнее Ингибирование TRPM7 каналов предотвращает пролиферацию и дифференцировку человеческих фибробластов легкихЦель: Переходный рецептор потенциал меластатин 7 (TRPM7) участвует в течении нормальных физиологических и патологических процессах.
20:00 / 16.02.2014 подробнее Bradykinin in health and disease: proceedings of the Bradykinin Symposium 2012, Berlin 23–24 August 2012The following summarises the plenary lectures of the ‘Bradykinin Symposium 2012’ held on 23−24 August 2012 at Charité-Universitätsmedizin Berlin, Germany.
20:00 / 04.08.2014 подробнее CX3CL1 (fractalkine) and TNFα production by perfused human placental lobules under normoxic and hypoxic conditions in vitro: the importance of CX3CR1 signalingObjective: Inflammation and hypoxia activate the fractalkine (CX3CL1) receptor (CX3CR1)-related signaling pathway. Tumor necrosis factor alpha (TNFα) induces CX3CL1, influencing a mechanism of CX3CL1 autoregulation by CX3CR1 expression.
20:00 / 04.08.2014 подробнее Wheal and flare reactions in skin prick tests of patients treated with montelukast alone or in combination with antihistaminesBackground: Because antileukotrienes may inhibit inflammation, it is plausible that montelukast administered for a long time could suppress skin wheal and flare reaction, and thus, it should be discarded prior to the tests.
20:00 / 04.08.2014 подробнее Anti-inflammatory effects of rutin on HMGB1-induced inflammatory responses in vitro and in vivoObjective and design: High mobility group box 1 (HMGB1) protein acts as a late mediator of severe vascular inflammatory conditions. Rutin (RT), an active flavonoid compound, is well known to possess potent antiplatelet, antiviral and antihypertensive properties.
20:00 / 04.08.2014 подробнее Opioid signaling in mast cells regulates injury responses associated with heterotopic ossificationIntroduction: Previous studies found that neuron specific enolase promoter (Nse-BMP4) transgenic mice have increased expression of the nociceptive mediator, substance P and exaggerated local injury responses associated with heterotopic ossification (HO).
20:00 / 04.08.2014 подробнее Effects of costimulation on intrahepatic immunopathogenesis in patients with chronic HBV infectionObjective: Chronic HBV infection can lead to “immune tolerance” in asymptomatic carriers (ACs), “immune injury” in active chronic hepatitis (ACH) patients or “immune abnormality” in cirrhosis (Cir) and hepatocellular carcinoma (HCC) patients.
20:00 / 04.08.2014 подробнее The significance of YKL-40 protein in liver fibrosisObjective: The aims of this review are to describe the present knowledge about YKL-40 protein, discuss its relation to liver fibrosis, and to look ahead at future perspectives of YKL-40 research.
20:00 / 04.08.2014 подробнее Linking GATA-3 and interleukin-13: implications in asthmaIntroduction: Asthma is one of the serious global health problems and cause of huge mortality and morbidity. It is characterized by persistent airway inflammation, airway hyperresponsiveness, increased IgE levels and mucus hypersecretion. Asthma is mediated by dominant Th2 immune response, causing enhanced expression of Th2 cytokines.
20:00 / 04.08.2014 подробнее Effect of lovastatin on coxsackievirus B3 infection in human endothelial cellsObjective: The coxsackie and adenovirus receptor (CAR) mediates the entry of coxsackievirus B (CVB) and adenovirus into host cells and is, therefore, a key determinant for the molecular pathogenesis of viral diseases such as myocarditis.
20:00 / 04.08.2014 подробнее