Inflammation research

Inflammation research

Influence of hemodialysis on circulating CD4<sup>low</sup>CD<sup>high</sup> regulatory T cells in end-stage renal disease patients

Objective: Immunodeficiency of end-stage renal disease (ESRD) is caused by several factors including uremic toxins and biocompatibility reactions due to the repeated hemodialysis (HD) procedure.

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Inflammaging: should this term be suitable for age related macular degeneration too?

Introduction: Inflammaging is a phenomenon triggered by the conjunction of chronic repetitive and subclinical inflammation from external aggressors and internal inflammatory mechanisms due to the progressive degradation of systems such as the mitochondrial function. 

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Biphasic activation of nuclear factor kappa B and expression of p65 and c-Rel after traumatic brain injury in rats

Nuclear factor kappa B (NF-κB) functions as a key regulator in the central nervous system and regulates the inflammatory pathway. There are two peaks of cerebral NF-κB activation after neonatal hypoxia–ischemia and subarachnoid hemorrhage.

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The expression of IL-2 and IL-4 in CD4+ T cells from mouse lymph nodes and spleen during HSV-1-induced facial palsy

Objective: Herpes simplex virus 1 (HSV-1) is regarded as an important underlying cause of Bell’s palsy, but the immunologic mechanism remains unknown.

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Anti-inflammatory and anti-arthritic effects of 3-hydroxy, 2-methoxy sodium butanoate from the leaves of Clerodendrum phlomidis L.f.

Introduction: The leaves of Clerodendrum phlomidis L.f. have been used in the Indian traditional system of medicine to treat several inflammatory diseases and arthritis. 

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Модель экспрессии Нискарина, вызванной липополисахарид (LPS)-индуцированным нейровоспалением в коре мозга крыс

Цель: Выяснить, участвует ли Нискарин через фосфатидилинозитол - 3 - киназу (PI3K) и РКВ-зивисимый путь в апоптозе нейронов, вызванном нейровоспалением.

  20:00 / 16.02.2014 подробнее  
Ингибирование продукции провосполительных цитокинов посредством ингибирования NF-κB сигнального пути в человеческих тучных клетках (линия HMC-1) с помощью Силибинина

Цель: Силибинин - главная активная молекула силимарина, извлеченная из Cirsium japonicum.

  20:00 / 16.02.2014 подробнее  
Подавление продукции цитокина Th1 пептидом, полученным из C4b

Цель: Система комплимента играет существенную роль в регулировании T-клеточных реакций. Однако, точный механизм, лежащий в основе C4-индуцируемой иммунотолерантности, остается неясным.

  20:00 / 16.02.2014 подробнее  
Ингибирование TRPM7 каналов предотвращает пролиферацию и дифференцировку человеческих фибробластов легких

Цель: Переходный рецептор потенциал меластатин 7 (TRPM7) участвует в течении нормальных физиологических и патологических процессах.

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Bradykinin in health and disease: proceedings of the Bradykinin Symposium 2012, Berlin 23–24 August 2012

The following summarises the plenary lectures of the ‘Bradykinin Symposium 2012’ held on 23−24 August 2012 at Charité-Universitätsmedizin Berlin, Germany. 

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CX3CL1 (fractalkine) and TNFα production by perfused human placental lobules under normoxic and hypoxic conditions in vitro: the importance of CX3CR1 signaling

Objective: Inflammation and hypoxia activate the fractalkine (CX3CL1) receptor (CX3CR1)-related signaling pathway. Tumor necrosis factor alpha (TNFα) induces CX3CL1, influencing a mechanism of CX3CL1 autoregulation by CX3CR1 expression. 

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Wheal and flare reactions in skin prick tests of patients treated with montelukast alone or in combination with antihistamines

Background: Because antileukotrienes may inhibit inflammation, it is plausible that montelukast administered for a long time could suppress skin wheal and flare reaction, and thus, it should be discarded prior to the tests. 

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Anti-inflammatory effects of rutin on HMGB1-induced inflammatory responses in vitro and in vivo

Objective and design: High mobility group box 1 (HMGB1) protein acts as a late mediator of severe vascular inflammatory conditions. Rutin (RT), an active flavonoid compound, is well known to possess potent antiplatelet, antiviral and antihypertensive properties.

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Opioid signaling in mast cells regulates injury responses associated with heterotopic ossification

Introduction: Previous studies found that neuron specific enolase promoter (Nse-BMP4) transgenic mice have increased expression of the nociceptive mediator, substance P and exaggerated local injury responses associated with heterotopic ossification (HO). 

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Effects of costimulation on intrahepatic immunopathogenesis in patients with chronic HBV infection

Objective: Chronic HBV infection can lead to “immune tolerance” in asymptomatic carriers (ACs), “immune injury” in active chronic hepatitis (ACH) patients or “immune abnormality” in cirrhosis (Cir) and hepatocellular carcinoma (HCC) patients.

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The significance of YKL-40 protein in liver fibrosis

Objective: The aims of this review are to describe the present knowledge about YKL-40 protein, discuss its relation to liver fibrosis, and to look ahead at future perspectives of YKL-40 research.

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Linking GATA-3 and interleukin-13: implications in asthma

Introduction: Asthma is one of the serious global health problems and cause of huge mortality and morbidity. It is characterized by persistent airway inflammation, airway hyperresponsiveness, increased IgE levels and mucus hypersecretion. Asthma is mediated by dominant Th2 immune response, causing enhanced expression of Th2 cytokines.

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Effect of lovastatin on coxsackievirus B3 infection in human endothelial cells

Objective: The coxsackie and adenovirus receptor (CAR) mediates the entry of coxsackievirus B (CVB) and adenovirus into host cells and is, therefore, a key determinant for the molecular pathogenesis of viral diseases such as myocarditis.

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Wnt5a, TLR2 and TLR4 are elevated in advanced human atherosclerotic lesions

Objective and design: Atherosclerosis (ATH) is a chronic inflammatory disease that involves cascades of signaling events mediated by various effector proteins.

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Intracranial injection of recombinant stromal-derived factor-1 alpha (SDF-1α) attenuates traumatic brain injury in rats

Objective: This study was conducted to investigate the role of stromal-derived factor-1 alpha (SDF-1α) in a secondary brain injury after traumatic brain injury (TBI) in rats, and to further elucidate its underlying regulatory mechanisms.

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