Н.В. Ломакин


Non-steroidal anti-inflammatory drugs and cardiovascular risks in the general population The Medicines and Healthcare products Regulatory Agency (MHRA) is the government agency responsible for regulating medicines and medical devices in the UK. We continually review the safety of all medicines in the UK, and inform healthcare professionals and the public of the latest updates. In our public assessment reports, we discuss the evidence on a safety issue associated with a particular drug or drug class.     20:00 / 18.03.2014 Читать полностью   Эффективность и безопасность нестероидного противовоспалительного средства лорноксикам у больных с острым коронарным синдромом без подъема сегмента ST Цель исследования состояла в оценке клинической эффективности, безопасности и влияния на маркеры воспаления нестероидного противовоспалительного средства лорноксикам у больных с острым коронарным синдромом без подъема сегмента ST. В проспективное рандомизированное исследование были включены 85 больных с острым коронарным синдромом без подъема сегмента ST.     20:00 / 17.03.2014 Читать полностью   A randomized placebo-controlled trial to assess the efficacy of antiinflammatory therapy with methylprednisolone in unstable angina (MUNA trial) The two groups were well balanced and had similar clinical characteristics at baseline. Forty-eight hours after randomization, mean C-reactive protein levels decreased by 2·6 mg . l-1 in the methylprednisolone group, but increased by 1·6 mg . l-1 in the placebo group (P = 0·03).     20:00 / 16.03.2014 Читать полностью   Do NSAIDs inhibit the cardioprotective effects of ASA? During the 5 years of follow-up, there were 378 myocardial infarctions: 139 in the ASA group and 239 in the placebo group (relative risk 0.56; 95% confidence interval [CI] 0.45–0.70).     20:00 / 16.03.2014 Читать полностью   Comparative antiplatelet activity of COX1 NSAIDS versus aspirin, encompassing regimen simplification and gastroprotection: a call for a controlled study The cardioprotective/platelet inhibitory role of Tnon-steroidal antiinflammatory drugs (NSAIDs) has been controversial, perhaps in contrast to the accepted prophylactic role of aspirin (114). That cardioprotective effect is attributed to the platelet aggregation inhibitory effects of aspirin and COX 1 active NSAIDS (10, 11, 13) and can be studied without requirement for massive numbers of patients.     20:00 / 16.03.2014 Читать полностью   Long-Term Outcome of Adjunctive Celecoxib Treatment After Paclitaxel-Eluting Stent Implantation for the Complex Coronary Lesions Drug-eluting stents (DES) are highly effective in reducing neointimal hyperplasia and need for repeat revascularization compared with bare-metal stents.1,2 However, restenosis is still a problem, especially in complex patients and lesions,3,4 leaving room for systemic adjunctive therapy after stent implantation.     20:00 / 16.03.2014 Читать полностью   Efficacy Assessment of Meloxicam, a Preferential Cyclooxygenase-2 Inhibitor, in Acute Coronary Syndromes Without ST-Segment Elevation Vessel wall inflammation influences the pathogenesis of unstable angina (UA), contributing to plaque instability and endothelial cell dysfunction.1–5 It is criti- cally involved in destabilizing atheroma, with inflammatory cells secreting proteolytic enzymes that degrade fibrous plaque, potentially constituting a thrombogenic stimulus.6,7 The fibrinolytic and matrix metalloproteinase systems, which are known to degrade extravascular matrix8 and may contribute to plaque disruption, are upregulated by proinflammatory mediators.     20:00 / 16.03.2014 Читать полностью   Which NSAID for your patient with osteoarthritis? Although clinicians have considerable experience in using analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs) to relieve the pain of osteoarthritis (OA), emerging data have made the task of weighing benefits and risks of each agent more complex.     20:00 / 18.02.2014 Читать полностью   Исторический обзор исследований воспаления в России В официальном журнале всемирного общества Воспаления Inflammation Research в 2013 году опубликован обзор: Buriachkovskaia L., Sumarokov A., Lomakin N. «Historical overview of the studies on inflammation in Russia». V. 62(5):441-450
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