Carla Enrica Gallenga, Francesco Parmeggiani, Ciro Costagliola, Adolfo Sebastiani, Pier Enrico Gallenga
Introduction: Inflammaging is a phenomenon triggered by the conjunction of chronic repetitive and subclinical inflammation from external aggressors and internal inflammatory mechanisms due to the progressive degradation of systems such as the mitochondrial function. Age-related macular degeneration is the leading cause of blindness and visual impairment in patients older than 60 years in developed countries.
Discussion: Remarkable correlations have been documented between common or rare immunological/inflammatory gene polymorphisms and AMD, unequivocally indicating the involvement of inflammation and immune-mediated processes (complement activation) in the pathogenesis of this disease.
Conclusion: Altogether these factors also drive this pathologic condition under the general heading of “Inflammaging”.